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This example shows how to setup TinyMCE to be more accessible for users with screen readers. Notice the native select elements, you can use keyboard shortcuts like Alt+Shift+Q (Toolbar), Alt+Shift+Z (Editor), Alt+Shift+X (Element path) and also tab to navigate the UI.
Below is all you need to setup the example.
<script type="text/javascript" src="<your installation path>/tiny_mce/tiny_mce.js"></script>
<script type="text/javascript">
tinyMCE.init({
mode : "textareas",
theme : "advanced",
plugins : "pagebreak,style,layer,table,save,advhr,advimage,advlink,emotions,iespell,insertdatetime,preview,media,searchreplace,print,contextmenu,paste,directionality,fullscreen,noneditable,visualchars,nonbreaking,xhtmlxtras,template",
theme_advanced_buttons1 : "save,newdocument,|,bold,italic,underline,strikethrough,|,justifyleft,justifycenter,justifyright,justifyfull,|,styleselect,formatselect,fontselect,fontsizeselect",
theme_advanced_buttons2 : "cut,copy,paste,pastetext,pasteword,|,search,replace,|,bullist,numlist,|,outdent,indent,blockquote,|,undo,redo,|,link,unlink,anchor,image,cleanup,help,code,|,insertdate,inserttime,preview,|,forecolor,backcolor",
theme_advanced_buttons3 : "tablecontrols,|,hr,removeformat,visualaid,|,sub,sup,|,charmap,emotions,iespell,media,advhr,|,print,|,ltr,rtl,|,fullscreen",
theme_advanced_buttons4 : "insertlayer,moveforward,movebackward,absolute,|,styleprops,|,cite,abbr,acronym,del,ins,attribs,|,visualchars,nonbreaking,template,pagebreak",
theme_advanced_toolbar_location : "top",
theme_advanced_toolbar_align : "left",
theme_advanced_statusbar_location : "bottom",
theme_advanced_resizing : true,
extended_valid_elements : "a[name|href|target|title|onclick],img[class|src|border=0|alt|title|hspace|vspace|width|height|align|onmouseover|onmouseout|name],hr[class|width|size|noshade],font[face|size|color|style],span[class|align|style]",
template_external_list_url : "example_template_list.js",
use_native_selects : true
});
</script>
<form method="post" action="somepage">
<textarea name="content" style="width:100%">
</textarea>
</form>